{"id":1199,"date":"2026-09-04T16:10:32","date_gmt":"2026-09-04T14:10:32","guid":{"rendered":"https:\/\/zentralkurs.lerbermatt.ch\/?p=1199"},"modified":"2026-09-04T16:10:33","modified_gmt":"2026-09-04T14:10:33","slug":"prodrugs-maskierte-wirkstoffmolekuele-2","status":"publish","type":"post","link":"https:\/\/zentralkurs.lerbermatt.ch\/?p=1199&lang=fr","title":{"rendered":"Prodrugs \u2013 maskierte Wirkstoffmolek\u00fcle"},"content":{"rendered":"\n<p class=\"has-large-font-size wp-block-paragraph\">Prof. Dr. Matthias Ducci | P\u00e4dagogische Hochschule Karlsruhe, Deutschland<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-04822461 wp-block-group-is-layout-flex wp-container-2 is-position-sticky\">\n<div class=\"wp-block-group wp-container-content-9cfa9a5a has-global-padding is-layout-constrained wp-block-group-is-layout-constrained wp-container-1 is-position-sticky\">\n<div class=\"wp-block-group has-text-color has-link-color wp-elements-1 is-layout-grid wp-container-core-group-is-layout-c4792de1 wp-block-group-is-layout-grid\" style=\"color:#01ab53\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-032bac08 wp-block-group-is-layout-grid\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-04822461 wp-block-group-is-layout-flex\">\n<div class=\"wp-block-font-awesome-icon wp-font-awesome-icon\" style=\"margin-right:var(--wp--preset--spacing--10);margin-left:0\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"fas\" data-icon=\"calendar-days\" class=\"svg-inline--fa fa-calendar-days \" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path fill=\"currentColor\" d=\"M128 0c17.7 0 32 14.3 32 32l0 32 128 0 0-32c0-17.7 14.3-32 32-32s32 14.3 32 32l0 32 32 0c35.3 0 64 28.7 64 64l0 288c0 35.3-28.7 64-64 64L64 480c-35.3 0-64-28.7-64-64L0 128C0 92.7 28.7 64 64 64l32 0 0-32c0-17.7 14.3-32 32-32zM64 240l0 32c0 8.8 7.2 16 16 16l32 0c8.8 0 16-7.2 16-16l0-32c0-8.8-7.2-16-16-16l-32 0c-8.8 0-16 7.2-16 16zm128 0l0 32c0 8.8 7.2 16 16 16l32 0c8.8 0 16-7.2 16-16l0-32c0-8.8-7.2-16-16-16l-32 0c-8.8 0-16 7.2-16 16zm144-16c-8.8 0-16 7.2-16 16l0 32c0 8.8 7.2 16 16 16l32 0c8.8 0 16-7.2 16-16l0-32c0-8.8-7.2-16-16-16l-32 0zM64 368l0 32c0 8.8 7.2 16 16 16l32 0c8.8 0 16-7.2 16-16l0-32c0-8.8-7.2-16-16-16l-32 0c-8.8 0-16 7.2-16 16zm144-16c-8.8 0-16 7.2-16 16l0 32c0 8.8 7.2 16 16 16l32 0c8.8 0 16-7.2 16-16l0-32c0-8.8-7.2-16-16-16l-32 0zm112 16l0 32c0 8.8 7.2 16 16 16l32 0c8.8 0 16-7.2 16-16l0-32c0-8.8-7.2-16-16-16l-32 0c-8.8 0-16 7.2-16 16z\"><\/path><\/svg><\/div>\n\n\n<div style=\"color:#01ab53\" class=\"has-link-color wp-elements-2 wp-block-post-date has-text-color has-medium-font-size\"><time datetime=\"2026-10-08T08:30:00\">Donnerstag, 8.10.2026<\/time><\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group wp-container-content-d2eb3c98 is-nowrap is-layout-flex wp-container-core-group-is-layout-04822461 wp-block-group-is-layout-flex\">\n<div class=\"wp-block-font-awesome-icon wp-font-awesome-icon\" style=\"margin-right:var(--wp--preset--spacing--10);margin-left:0\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"fas\" data-icon=\"clock\" class=\"svg-inline--fa fa-clock \" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path fill=\"currentColor\" d=\"M256 0a256 256 0 1 1 0 512 256 256 0 1 1 0-512zM232 120l0 136c0 8 4 15.5 10.7 20l96 64c11 7.4 25.9 4.4 33.3-6.7s4.4-25.9-6.7-33.3L280 243.2 280 120c0-13.3-10.7-24-24-24s-24 10.7-24 24z\"><\/path><\/svg><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">08:30 &#8211; 09:15 | 45 Min.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-text-color has-link-color wp-elements-3 is-layout-grid wp-container-core-group-is-layout-c4792de1 wp-block-group-is-layout-grid\" style=\"color:#01ab53\">\n<div class=\"wp-block-group wp-container-content-d2eb3c98 is-nowrap is-layout-flex wp-container-core-group-is-layout-04822461 wp-block-group-is-layout-flex\">\n<div class=\"wp-block-font-awesome-icon wp-font-awesome-icon\" style=\"margin-right:var(--wp--preset--spacing--10)\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"fas\" data-icon=\"compass\" class=\"svg-inline--fa fa-compass \" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path fill=\"currentColor\" d=\"M256 512a256 256 0 1 0 0-512 256 256 0 1 0 0 512zm50.7-186.9L162.4 380.6c-19.4 7.5-38.5-11.6-31-31l55.5-144.3c3.3-8.5 9.9-15.1 18.4-18.4l144.3-55.5c19.4-7.5 38.5 11.6 31 31L325.1 306.7c-3.2 8.5-9.9 15.1-18.4 18.4zM288 256a32 32 0 1 0 -64 0 32 32 0 1 0 64 0z\"><\/path><\/svg><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Aula<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-04822461 wp-block-group-is-layout-flex\">\n<div class=\"wp-block-font-awesome-icon wp-font-awesome-icon\" style=\"margin-right:var(--wp--preset--spacing--10)\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"fas\" data-icon=\"language\" class=\"svg-inline--fa fa-language \" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 576 512\"><path fill=\"currentColor\" d=\"M160 0c17.7 0 32 14.3 32 32l0 32 128 0c17.7 0 32 14.3 32 32s-14.3 32-32 32l-9.6 0-8.4 23.1c-16.4 45.2-41.1 86.5-72.2 122 14.2 8.8 29 16.6 44.4 23.5l50.4 22.4 62.2-140c5.1-11.6 16.6-19 29.2-19s24.1 7.4 29.2 19l128 288c7.2 16.2-.1 35.1-16.2 42.2s-35.1-.1-42.2-16.2l-20-45-157.5 0-20 45c-7.2 16.2-26.1 23.4-42.2 16.2s-23.4-26.1-16.2-42.2l39.8-89.5-50.4-22.4c-23-10.2-45-22.4-65.8-36.4-21.3 17.2-44.6 32.2-69.5 44.7L78.3 380.6c-15.8 7.9-35 1.5-42.9-14.3s-1.5-35 14.3-42.9l34.5-17.3c16.3-8.2 31.8-17.7 46.4-28.3-13.8-12.7-26.8-26.4-38.9-40.9L81.6 224.7c-11.3-13.6-9.5-33.8 4.1-45.1s33.8-9.5 45.1 4.1l10.2 12.2c11.5 13.9 24.1 26.8 37.4 38.7 27.5-30.4 49.2-66.1 63.5-105.4l.5-1.2-210.3 0C14.3 128 0 113.7 0 96S14.3 64 32 64l96 0 0-32c0-17.7 14.3-32 32-32zM416 270.8L365.7 384 466.3 384 416 270.8z\"><\/path><\/svg><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Deutsch<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-image size-large wp-container-content-1387b69e\"><a href=\"https:\/\/www.ph-karlsruhe.de\/personen\/detail\/z2hdzk\" target=\"_blank\" rel=\" noopener\"><img decoding=\"async\" src=\"https:\/\/www.ph-karlsruhe.de\/fileadmin\/_processed_\/0\/8\/csm_z2hdzk_de_Passfoto_Ducci-5bfeb5894d4a20e2_271c182d73.webp\" alt=\"\"\/><\/a><figcaption class=\"wp-element-caption\">Ref: PH Karlsruhe<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Beschreibung<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Um Medikamente zur Therapie von Erkrankungen gezielt im Organismus zur Wirkung zu bringen, greift die pharmazeutische Industrie mitunter tief in die biochemische Trickkiste. \u00dcberraschend prominente Arzneimittel funktionieren nach dem Prodrug-Konzept.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Im Experimentalvortrag werden&nbsp;umfangreiche Anregungen (Unterrichtskonzept, Experimente, Modelle) gegeben, auf welche Weise diese spannende und f\u00e4cher\u00fcbergreifende Thematik forschend-entwickelnd in den naturwissenschaftlichen Unterricht (Chemie, Biologie) der Sekundarstufe II implementiert werden kann.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Als Modellsubstanz dient 5-Aminosalicyls\u00e4ure (5-ASA). Sie wird aufgrund ihrer entz\u00fcndungshemmenden Wirkung in Arzneimitteln gegen Darmerkrankungen, wie z. B. Morbus Crohn und Colitis ulcerosa, eingesetzt. In unver\u00e4nderter Form ist diese Verbindung in magensaftresistenten Tabletten enthalten, um die fr\u00fchzeitige Resorption und anschlie\u00dfende Metabolisierung zu verhindern. Eine andere Strategie wird mit dem Prodrug-Konzept verfolgt: Hierzu wird 5-ASA z. B. in Azosalicyls\u00e4ure, eine stabile Verbindung ohne eigene biologische Aktivit\u00e4t, \u00fcberf\u00fchrt. Diese Verbindung wird dann im Darm durch bakterielle Azoreduktasen in aktive 5-ASA-Molek\u00fcle gespalten.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Bemerkungen<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Experimentalvortrag<br><a href=\"https:\/\/zentralkurs.lerbermatt.ch\/?p=575\" data-type=\"post\" data-id=\"575\">Workshop Do 8.10.16, 14:45<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-3&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading has-icon has-icon-right has-background has-medium-font-size\" style=\"border-style:none;border-width:0px;border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-left-radius:0px;border-bottom-right-radius:0px;background-color:#fae5cd\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-3-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" id=\"accordion-item-3\" type=\"button\" class=\"wp-block-accordion-heading__toggle\" style=\"padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)\"><span class=\"wp-block-accordion-heading__toggle-title\">Kontaktangaben<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div aria-labelledby=\"accordion-item-3\" data-wp-bind--hidden=\"state.isHidden\" data-wp-on--beforematch=\"actions.handleBeforeMatch\" id=\"accordion-item-3-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-52134f89 wp-block-group-is-layout-flex\" style=\"padding-left:30px\">\n<div class=\"wp-block-font-awesome-icon wp-font-awesome-icon\" style=\"margin-right:5px\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"fas\" data-icon=\"at\" class=\"svg-inline--fa fa-at \" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path fill=\"currentColor\" d=\"M256 64C150 64 64 150 64 256s86 192 192 192c17.7 0 32 14.3 32 32s-14.3 32-32 32C114.6 512 0 397.4 0 256S114.6 0 256 0 512 114.6 512 256l0 32c0 53-43 96-96 96-29.3 0-55.6-13.2-73.2-33.9-22.8 21-53.3 33.9-86.8 33.9-70.7 0-128-57.3-128-128s57.3-128 128-128c27.9 0 53.7 8.9 74.7 24.1 5.7-5 13.1-8.1 21.3-8.1 17.7 0 32 14.3 32 32l0 112c0 17.7 14.3 32 32 32s32-14.3 32-32l0-32c0-106-86-192-192-192zm64 192a64 64 0 1 0 -128 0 64 64 0 1 0 128 0z\"><\/path><\/svg><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"mailto:ducci@ph-karlsruhe.de\" target=\"_blank\" rel=\"noopener\">ducci@ph-karlsruhe.de<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-57a6f699 wp-block-group-is-layout-flex\" style=\"padding-left:56px\">\n<p class=\"wp-block-paragraph\">P\u00e4dagogische Hochschule Karlsruhe, Institut f\u00fcr Chemie<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-57a6f699 wp-block-group-is-layout-flex\" style=\"padding-left:56px\">\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.ph-karlsruhe.de\" target=\"_blank\" rel=\"noopener\">www.ph-karlsruhe.de<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-4&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading has-icon has-icon-right has-background has-medium-font-size\" style=\"background-color:#fae5cd\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-4-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" id=\"accordion-item-4\" type=\"button\" class=\"wp-block-accordion-heading__toggle\" style=\"padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)\"><span class=\"wp-block-accordion-heading__toggle-title\">Unterlagen<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div aria-labelledby=\"accordion-item-4\" data-wp-bind--hidden=\"state.isHidden\" data-wp-on--beforematch=\"actions.handleBeforeMatch\" id=\"accordion-item-4-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-04822461 wp-block-group-is-layout-flex\">\n<div style=\"height:100px;width:0px\" aria-hidden=\"true\" class=\"wp-block-spacer wp-container-content-16d1eb73\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">keine<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prof. Dr. Matthias Ducci | P\u00e4dagogische Hochschule Karlsruhe, Deutschland 08:30 &#8211; 09:15 | 45 Min. Aula Deutsch Beschreibung Um Medikamente zur Therapie von Erkrankungen gezielt im Organismus zur Wirkung zu bringen, greift die pharmazeutische Industrie mitunter tief in die biochemische Trickkiste. \u00dcberraschend prominente Arzneimittel funktionieren nach dem Prodrug-Konzept. Im Experimentalvortrag werden&nbsp;umfangreiche Anregungen (Unterrichtskonzept, Experimente, Modelle) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"cc26-fran-ais","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[66],"tags":[],"class_list":["post-1199","post","type-post","status-publish","format-standard","hentry","category-vortraege-fr"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/zentralkurs.lerbermatt.ch\/index.php?rest_route=\/wp\/v2\/posts\/1199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zentralkurs.lerbermatt.ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zentralkurs.lerbermatt.ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zentralkurs.lerbermatt.ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/zentralkurs.lerbermatt.ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1199"}],"version-history":[{"count":1,"href":"https:\/\/zentralkurs.lerbermatt.ch\/index.php?rest_route=\/wp\/v2\/posts\/1199\/revisions"}],"predecessor-version":[{"id":1200,"href":"https:\/\/zentralkurs.lerbermatt.ch\/index.php?rest_route=\/wp\/v2\/posts\/1199\/revisions\/1200"}],"wp:attachment":[{"href":"https:\/\/zentralkurs.lerbermatt.ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zentralkurs.lerbermatt.ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1199"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zentralkurs.lerbermatt.ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}